SHORT RNA GUIDES CLEAVAGE BY EUKARYOTIC RNASE III.

Short RNA guides cleavage by eukaryotic RNase III.

In eukaryotes, short RNAs guide a variety of enzymatic activities that range from RNA editing to Marvel translation repression.It is hypothesized that pre-existing proteins evolved to bind and use guide RNA during evolution.However, the capacity of modern proteins to adopt new RNA guides has never been demonstrated.Here we show that Rnt1p, the yeas

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Intrinsically disordered proteins studied by NMR spectroscopy

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of complex multi-domain proteins are now identified as a trend topic by the scientific community.NMR constitutes a unique investigation tool to access atom resolved information on their structural Valve Covers and dynamic properties, in isolation or upon interactio

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